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The four residents including the new Dr. Morgan Reznick are paired off in competition; Reznick and Browne with Melendez, Murphy and Kalu with Lim. Murphy and Kalu are faced with agender dysphoric patient, Quinn, which leads to friction when Murphy claims people can only be their biological gender. Murphy and Kalu determine that Quinn has testicular cancer along with fragile bones caused by puberty blockers. Browne and Reznick tend to a male patient that has contracted a superbug resistant to all medication, as a result of taking leftover prescription medication for the wrong purpose. Drs. Andrews and Barnes see a fertility specialist as they are having trouble conceiving.